2021 Conference USA Leaders Passes Defended - Games in August/September Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 4 | 5 | 13 | 18 | 4.50 |
| 2 | UAB | 4 | 4 | 19 | 23 | 5.75 |
| 3 | Rice | 4 | 3 | 11 | 14 | 3.50 |
| 3 | Middle Tennessee | 4 | 3 | 10 | 13 | 3.25 |
| 3 | Louisiana Tech | 4 | 3 | 9 | 12 | 3.00 |
| 3 | Marshall | 4 | 3 | 9 | 12 | 3.00 |
| 3 | North Texas | 4 | 3 | 6 | 9 | 2.25 |
| 8 | UTEP | 4 | 2 | 15 | 17 | 4.25 |
| 8 | Southern Mississippi | 4 | 2 | 10 | 12 | 3.00 |
| 10 | Florida International | 4 | 1 | 15 | 16 | 4.00 |
| 10 | Charlotte | 4 | 1 | 12 | 13 | 3.25 |
| 10 | UTSA | 4 | 1 | 12 | 13 | 3.25 |
| 10 | Western Kentucky | 3 | 1 | 10 | 11 | 3.67 |
| 14 | Old Dominion | 4 | 0 | 8 | 8 | 2.00 |