2021 Conference USA Leaders Passes Defended - Games Lost Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Southern Miss | 9 | 6 | 23 | 29 | 3.22 |
| 1 | Louisiana Tech | 9 | 6 | 21 | 27 | 3.00 |
| 1 | Charlotte | 7 | 6 | 11 | 17 | 2.43 |
| 4 | Middle Tennessee State | 6 | 5 | 23 | 28 | 4.67 |
| 4 | Rice | 8 | 5 | 22 | 27 | 3.38 |
| 4 | Florida Atlantic | 7 | 5 | 20 | 25 | 3.57 |
| 7 | FIU | 11 | 3 | 26 | 29 | 2.64 |
| 7 | Old Dominion | 7 | 3 | 25 | 28 | 4.00 |
| 7 | North Texas | 7 | 3 | 9 | 12 | 1.71 |
| 10 | Marshall | 6 | 2 | 26 | 28 | 4.67 |
| 11 | UTEP | 6 | 1 | 20 | 21 | 3.50 |
| 11 | Western Kentucky | 5 | 1 | 14 | 15 | 3.00 |
| 11 | UAB | 4 | 1 | 7 | 8 | 2.00 |
| 14 | UTSA | 2 | 0 | 2 | 2 | 1.00 |