2021 Conference USA Leaders Turnover Margin - Games in August/September Only through 01/10/2022
| Name | G | Fum. Gain | Int. Gain | Total Gain | Fum. Lost | Int. Lost | Total Lost | Margin | Margin/G | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 4 | 1 | 5 | 6 | 5 | 1 | 6 | 0 | 0.00 |
| 2 | UAB | 4 | 2 | 4 | 6 | 3 | 4 | 7 | -1 | -0.25 |
| 3 | Middle Tennessee | 4 | 5 | 3 | 8 | 1 | 2 | 3 | 5 | 1.25 |
| 3 | North Texas | 4 | 6 | 3 | 9 | 1 | 5 | 6 | 3 | 0.75 |
| 3 | Louisiana Tech | 4 | 5 | 3 | 8 | 2 | 3 | 5 | 3 | 0.75 |
| 3 | Marshall | 4 | 4 | 3 | 7 | 3 | 6 | 9 | -2 | -0.50 |
| 3 | Rice | 4 | 0 | 3 | 3 | 3 | 7 | 10 | -7 | -1.75 |
| 8 | Southern Mississippi | 4 | 3 | 2 | 5 | 3 | 5 | 8 | -3 | -0.75 |
| 8 | UTEP | 4 | 4 | 2 | 6 | 4 | 6 | 10 | -4 | -1.00 |
| 10 | UTSA | 4 | 6 | 1 | 7 | 3 | 2 | 5 | 2 | 0.50 |
| 10 | Western Kentucky | 3 | 2 | 1 | 3 | 0 | 2 | 2 | 1 | 0.33 |
| 10 | Charlotte | 4 | 4 | 1 | 5 | 2 | 2 | 4 | 1 | 0.25 |
| 10 | Florida International | 4 | 2 | 1 | 3 | 4 | 3 | 7 | -4 | -1.00 |
| 14 | Old Dominion | 4 | 3 | 0 | 3 | 2 | 4 | 6 | -3 | -0.75 |