2021 Conference USA Leaders Rushing Offense - Games in August/September Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTSA | 4 | 185 | 703 | 3.80 | 8 | 46.25 | 175.75 |
| 2 | North Texas | 4 | 184 | 832 | 4.52 | 5 | 46.00 | 208.00 |
| 3 | Old Dominion | 4 | 173 | 776 | 4.49 | 9 | 43.25 | 194.00 |
| 4 | UAB | 4 | 172 | 640 | 3.72 | 4 | 43.00 | 160.00 |
| 5 | UTEP | 4 | 166 | 657 | 3.96 | 5 | 41.50 | 164.25 |
| 5 | Southern Mississippi | 4 | 166 | 496 | 2.99 | 3 | 41.50 | 124.00 |
| 7 | Charlotte | 4 | 165 | 782 | 4.74 | 7 | 41.25 | 195.50 |
| 8 | Rice | 4 | 159 | 700 | 4.40 | 7 | 39.75 | 175.00 |
| 9 | Florida Atlantic | 4 | 150 | 675 | 4.50 | 6 | 37.50 | 168.75 |
| 10 | Louisiana Tech | 4 | 137 | 511 | 3.73 | 7 | 34.25 | 127.75 |
| 11 | Marshall | 4 | 136 | 675 | 4.96 | 14 | 34.00 | 168.75 |
| 12 | Florida International | 4 | 129 | 556 | 4.31 | 6 | 32.25 | 139.00 |
| 13 | Middle Tennessee | 4 | 118 | 293 | 2.48 | 2 | 29.50 | 73.25 |
| 14 | Western Kentucky | 3 | 64 | 244 | 3.81 | 3 | 21.33 | 81.33 |