2021 Conference USA Leaders Total Offense - Games Lost Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 5 | 345 | 2388 | 379 | 2733 | 7.21 | 546.6 |
| 2 | UAB | 4 | 647 | 772 | 230 | 1419 | 6.17 | 354.8 |
| 3 | UTSA | 2 | 317 | 416 | 124 | 733 | 5.91 | 366.5 |
| 4 | Marshall | 6 | 859 | 1554 | 414 | 2413 | 5.83 | 402.2 |
| 5 | UTEP | 6 | 642 | 1591 | 389 | 2233 | 5.74 | 372.2 |
| 6 | Louisiana Tech | 9 | 1009 | 2360 | 619 | 3369 | 5.44 | 374.3 |
| 6 | Florida International | 11 | 907 | 2906 | 701 | 3813 | 5.44 | 346.6 |
| 8 | Charlotte | 7 | 898 | 1722 | 486 | 2620 | 5.39 | 374.3 |
| 9 | Middle Tennessee | 6 | 456 | 1622 | 422 | 2078 | 4.92 | 346.3 |
| 10 | Florida Atlantic | 7 | 744 | 1560 | 478 | 2304 | 4.82 | 329.1 |
| 11 | North Texas | 7 | 1283 | 1454 | 572 | 2737 | 4.78 | 391.0 |
| 12 | Rice | 8 | 1013 | 1611 | 551 | 2624 | 4.76 | 328.0 |
| 13 | Old Dominion | 7 | 904 | 1285 | 489 | 2189 | 4.48 | 312.7 |
| 14 | Southern Mississippi | 9 | 653 | 1365 | 566 | 2018 | 3.57 | 224.2 |