2021 Conference USA Leaders Total Offense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 5 | 531 | 2188 | 350 | 2719 | 7.77 | 543.8 |
| 2 | Marshall | 5 | 862 | 1628 | 356 | 2490 | 6.99 | 498.0 |
| 3 | Florida International | 4 | 556 | 1121 | 249 | 1677 | 6.73 | 419.3 |
| 4 | Louisiana Tech | 4 | 571 | 1210 | 280 | 1781 | 6.36 | 445.3 |
| 5 | UTEP | 5 | 755 | 1260 | 322 | 2015 | 6.26 | 403.0 |
| 6 | UAB | 5 | 863 | 998 | 316 | 1861 | 5.89 | 372.2 |
| 7 | Charlotte | 4 | 656 | 841 | 257 | 1497 | 5.82 | 374.3 |
| 8 | North Texas | 5 | 989 | 1311 | 406 | 2300 | 5.67 | 460.0 |
| 9 | Florida Atlantic | 4 | 675 | 972 | 291 | 1647 | 5.66 | 411.8 |
| 10 | UTSA | 5 | 749 | 1328 | 368 | 2077 | 5.64 | 415.4 |
| 11 | Rice | 4 | 700 | 712 | 260 | 1412 | 5.43 | 353.0 |
| 12 | Middle Tennessee | 5 | 511 | 1355 | 368 | 1866 | 5.07 | 373.2 |
| 13 | Old Dominion | 5 | 847 | 872 | 354 | 1719 | 4.86 | 343.8 |
| 14 | Southern Mississippi | 4 | 496 | 570 | 270 | 1066 | 3.95 | 266.5 |