2021 Conference USA Leaders Interceptions - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 7 | 10 | 145 | 2 | 1.43 |
| 2 | Florida Atlantic | 6 | 5 | 123 | 1 | 0.83 |
| 3 | Middle Tennessee | 5 | 8 | 112 | 0 | 1.60 |
| 4 | Louisiana Tech | 6 | 3 | 92 | 1 | 0.50 |
| 5 | Southern Mississippi | 5 | 5 | 70 | 1 | 1.00 |
| 6 | UAB | 6 | 3 | 66 | 1 | 0.50 |
| 7 | North Texas | 7 | 4 | 39 | 0 | 0.57 |
| 8 | Marshall | 6 | 2 | 35 | 0 | 0.33 |
| 9 | Rice | 6 | 5 | 31 | 0 | 0.83 |
| 9 | Old Dominion | 7 | 4 | 31 | 0 | 0.57 |
| 11 | UTSA | 6 | 5 | 10 | 0 | 0.83 |
| 12 | UTEP | 4 | 1 | 5 | 0 | 0.25 |
| 13 | Charlotte | 4 | 3 | 0 | 0 | 0.75 |
| 13 | Florida International | 5 | 1 | 0 | 0 | 0.20 |