2021 Conference USA Leaders First Downs - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | UTEP | 5 | 34 | 43 | 14 | 91 | 18.2 |
| 2 | UTSA | 5 | 41 | 61 | 13 | 115 | 23.0 |
| 3 | Rice | 4 | 31 | 36 | 12 | 79 | 19.8 |
| 4 | North Texas | 5 | 54 | 57 | 11 | 122 | 24.4 |
| 5 | Louisiana Tech | 4 | 27 | 52 | 10 | 89 | 22.3 |
| 6 | Old Dominion | 5 | 52 | 40 | 9 | 101 | 20.2 |
| 7 | Western Kentucky | 5 | 34 | 87 | 8 | 129 | 25.8 |
| 7 | Florida Atlantic | 4 | 39 | 45 | 8 | 92 | 23.0 |
| 7 | Middle Tennessee | 5 | 40 | 59 | 8 | 107 | 21.4 |
| 7 | Southern Mississippi | 4 | 32 | 26 | 8 | 66 | 16.5 |
| 11 | Charlotte | 4 | 35 | 36 | 7 | 78 | 19.5 |
| 12 | Florida International | 4 | 23 | 42 | 6 | 71 | 17.8 |
| 13 | UAB | 5 | 45 | 42 | 5 | 92 | 18.4 |
| 14 | Marshall | 5 | 52 | 63 | 3 | 118 | 23.6 |