2021 Conference USA Leaders Tackles For Loss Allowed - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Old Dominion | 1 | 7.0 | 18 | 7.00 |
| 2 | Florida International | 1 | 4.0 | 19 | 4.00 |
| 2 | UTSA | 1 | 6.0 | 19 | 6.00 |
| 4 | Southern Mississippi | 1 | 6.0 | 27 | 6.00 |
| 4 | Rice | 2 | 11.0 | 27 | 5.50 |
| 6 | UAB | 1 | 6.0 | 34 | 6.00 |
| 6 | Middle Tennessee | 1 | 9.0 | 34 | 9.00 |
| 6 | North Texas | 1 | 10.0 | 34 | 10.00 |
| 9 | Louisiana Tech | 2 | 9.0 | 35 | 4.50 |
| 10 | Florida Atlantic | 1 | 6.0 | 36 | 6.00 |
| 11 | Western Kentucky | 2 | 8.0 | 38 | 4.00 |
| 12 | Charlotte | 2 | 14.0 | 58 | 7.00 |