2021 Conference USA Leaders Scoring Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | UTSA | 1 | 3 | 3 | 3 | 0 | 0 | 30 | 30.0 |
| 2 | Florida Atlantic | 1 | 5 | 0 | 5 | 0 | 0 | 35 | 35.0 |
| 2 | Middle Tennessee State | 1 | 5 | 0 | 5 | 0 | 0 | 35 | 35.0 |
| 4 | Old Dominion | 1 | 6 | 0 | 6 | 0 | 0 | 42 | 42.0 |
| 5 | North Texas | 1 | 6 | 2 | 6 | 0 | 0 | 48 | 48.0 |
| 6 | Charlotte | 2 | 7 | 1 | 7 | 0 | 0 | 52 | 26.0 |
| 7 | FIU | 1 | 7 | 2 | 6 | 0 | 0 | 54 | 54.0 |
| 8 | UAB | 1 | 8 | 0 | 8 | 0 | 0 | 56 | 56.0 |
| 9 | Southern Miss | 1 | 9 | 0 | 9 | 0 | 0 | 63 | 63.0 |
| 10 | Louisiana Tech | 2 | 9 | 2 | 9 | 0 | 0 | 69 | 34.5 |
| 11 | Western Kentucky | 2 | 9 | 6 | 9 | 0 | 0 | 81 | 40.5 |
| 12 | Rice | 2 | 13 | 1 | 13 | 0 | 1 | 96 | 48.0 |