2021 Conference USA Leaders Scoring Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 11 | 29 | 6 | 24 | 1 | 0 | 218 | 19.8 |
| 2 | Southern Mississippi | 11 | 33 | 13 | 33 | 0 | 1 | 272 | 24.7 |
| 3 | Marshall | 12 | 35 | 10 | 33 | 0 | 0 | 273 | 22.8 |
| 4 | UTSA | 13 | 39 | 13 | 32 | 1 | 0 | 307 | 23.6 |
| 5 | Florida Atlantic | 12 | 39 | 10 | 35 | 3 | 2 | 309 | 25.8 |
| 6 | Old Dominion | 12 | 38 | 18 | 35 | 1 | 0 | 319 | 26.6 |
| 7 | UTEP | 13 | 40 | 16 | 38 | 0 | 1 | 328 | 25.2 |
| 8 | Middle Tennessee | 13 | 42 | 12 | 40 | 2 | 1 | 334 | 25.7 |
| 9 | Rice | 10 | 46 | 9 | 45 | 0 | 2 | 352 | 35.2 |
| 10 | North Texas | 13 | 46 | 12 | 45 | 0 | 0 | 357 | 27.5 |
| 11 | Western Kentucky | 13 | 47 | 12 | 45 | 0 | 0 | 363 | 27.9 |
| 12 | Louisiana Tech | 11 | 49 | 10 | 46 | 1 | 1 | 374 | 34.0 |
| 13 | Charlotte | 12 | 55 | 8 | 52 | 1 | 0 | 408 | 34.0 |
| 14 | Florida International | 12 | 62 | 15 | 57 | 0 | 1 | 476 | 39.7 |