2021 Conference USA Leaders Passing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 1 | 35 | 20 | 57.1 | 153 | 4.4 | 1 | 2 | 91.86 | 35.0 | 153.0 |
| 1 | Rice | 2 | 42 | 29 | 69.0 | 321 | 7.6 | 3 | 2 | 147.30 | 21.0 | 160.5 |
| 3 | Louisiana Tech | 2 | 83 | 61 | 73.5 | 621 | 7.5 | 5 | 1 | 153.81 | 41.5 | 310.5 |
| 3 | UAB | 1 | 22 | 14 | 63.6 | 376 | 17.1 | 6 | 1 | 288.11 | 22.0 | 376.0 |
| 3 | Southern Mississippi | 1 | 26 | 23 | 88.5 | 395 | 15.2 | 6 | 1 | 284.53 | 26.0 | 395.0 |
| 6 | Charlotte | 2 | 48 | 30 | 62.5 | 306 | 6.4 | 2 | 0 | 129.80 | 24.0 | 153.0 |
| 6 | Middle Tennessee | 1 | 28 | 17 | 60.7 | 159 | 5.7 | 1 | 0 | 120.19 | 28.0 | 159.0 |
| 6 | North Texas | 1 | 34 | 22 | 64.7 | 168 | 4.9 | 2 | 0 | 125.62 | 34.0 | 168.0 |
| 6 | Old Dominion | 1 | 29 | 18 | 62.1 | 188 | 6.5 | 3 | 0 | 150.67 | 29.0 | 188.0 |
| 6 | UTSA | 1 | 43 | 22 | 51.2 | 266 | 6.2 | 3 | 0 | 126.14 | 43.0 | 266.0 |
| 6 | Western Kentucky | 2 | 83 | 55 | 66.3 | 700 | 8.4 | 1 | 0 | 141.10 | 41.5 | 350.0 |
| 6 | Florida International | 1 | 37 | 27 | 73.0 | 407 | 11.0 | 4 | 0 | 201.05 | 37.0 | 407.0 |