2021 Conference USA Leaders Passing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 4 | 104 | 52 | 50.0 | 549 | 5.3 | 3 | 5 | 94.24 | 26.0 | 137.3 |
| 2 | UAB | 4 | 141 | 74 | 52.5 | 866 | 6.1 | 10 | 4 | 121.80 | 35.3 | 216.5 |
| 3 | Marshall | 4 | 138 | 74 | 53.6 | 845 | 6.1 | 5 | 3 | 112.66 | 34.5 | 211.3 |
| 3 | Rice | 4 | 111 | 72 | 64.9 | 927 | 8.4 | 6 | 3 | 147.45 | 27.8 | 231.8 |
| 3 | North Texas | 4 | 101 | 63 | 62.4 | 956 | 9.5 | 9 | 3 | 165.36 | 25.3 | 239.0 |
| 3 | Middle Tennessee | 4 | 151 | 95 | 62.9 | 961 | 6.4 | 8 | 3 | 129.88 | 37.8 | 240.3 |
| 3 | Louisiana Tech | 4 | 193 | 134 | 69.4 | 1352 | 7.0 | 12 | 3 | 145.68 | 48.3 | 338.0 |
| 8 | UTEP | 4 | 119 | 58 | 48.7 | 812 | 6.8 | 4 | 2 | 113.79 | 29.8 | 203.0 |
| 8 | Southern Mississippi | 4 | 120 | 83 | 69.2 | 1009 | 8.4 | 10 | 2 | 163.97 | 30.0 | 252.3 |
| 10 | Charlotte | 4 | 103 | 60 | 58.3 | 796 | 7.7 | 8 | 1 | 146.86 | 25.8 | 199.0 |
| 10 | UTSA | 4 | 111 | 57 | 51.4 | 819 | 7.4 | 6 | 1 | 129.37 | 27.8 | 204.8 |
| 10 | Western Kentucky | 3 | 102 | 60 | 58.8 | 645 | 6.3 | 2 | 1 | 116.45 | 34.0 | 215.0 |
| 10 | Florida International | 4 | 148 | 91 | 61.5 | 1164 | 7.9 | 10 | 1 | 148.51 | 37.0 | 291.0 |
| 14 | Old Dominion | 4 | 100 | 63 | 63.0 | 708 | 7.1 | 9 | 0 | 152.17 | 25.0 | 177.0 |