2021 Conference USA Leaders Passing Defense - Games in October Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 4 | 81 | 49 | 60.5 | 642 | 7.9 | 3 | 2 | 134.35 | 20.3 | 160.5 |
| 2 | UAB | 4 | 95 | 59 | 62.1 | 809 | 8.5 | 6 | 4 | 146.06 | 23.8 | 202.3 |
| 3 | Charlotte | 4 | 105 | 71 | 67.6 | 1162 | 11.1 | 12 | 3 | 192.59 | 26.3 | 290.5 |
| 4 | Marshall | 4 | 111 | 57 | 51.4 | 525 | 4.7 | 3 | 6 | 89.19 | 27.8 | 131.3 |
| 5 | Rice | 4 | 118 | 69 | 58.5 | 904 | 7.7 | 4 | 5 | 125.55 | 29.5 | 226.0 |
| 6 | Louisiana Tech | 4 | 119 | 76 | 63.9 | 876 | 7.4 | 5 | 2 | 136.21 | 29.8 | 219.0 |
| 7 | UTEP | 4 | 120 | 68 | 56.7 | 768 | 6.4 | 4 | 5 | 113.10 | 30.0 | 192.0 |
| 8 | North Texas | 4 | 136 | 83 | 61.0 | 1067 | 7.8 | 10 | 1 | 149.73 | 34.0 | 266.8 |
| 8 | Florida International | 4 | 136 | 109 | 80.1 | 1199 | 8.8 | 10 | 0 | 178.46 | 34.0 | 299.8 |
| 10 | UTSA | 4 | 152 | 98 | 64.5 | 1214 | 8.0 | 9 | 7 | 141.89 | 38.0 | 303.5 |
| 11 | Florida Atlantic | 4 | 154 | 82 | 53.2 | 1098 | 7.1 | 7 | 5 | 121.65 | 38.5 | 274.5 |
| 12 | Middle Tennessee | 4 | 155 | 87 | 56.1 | 964 | 6.2 | 5 | 10 | 106.12 | 38.8 | 241.0 |
| 13 | Old Dominion | 4 | 163 | 101 | 62.0 | 1163 | 7.1 | 10 | 3 | 138.46 | 40.8 | 290.8 |
| 14 | Western Kentucky | 5 | 174 | 109 | 62.6 | 1417 | 8.1 | 9 | 4 | 143.52 | 34.8 | 283.4 |