2021 Conference USA Leaders Scoring Defense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 5 | 12 | 4 | 9 | 2 | 2 | 101 | 20.2 |
| 2 | Marshall | 6 | 10 | 4 | 10 | 0 | 0 | 82 | 13.7 |
| 3 | Western Kentucky | 6 | 14 | 9 | 12 | 0 | 0 | 123 | 20.5 |
| 4 | UAB | 6 | 15 | 2 | 13 | 0 | 0 | 109 | 18.2 |
| 5 | UTEP | 8 | 16 | 6 | 15 | 0 | 0 | 129 | 16.1 |
| 5 | North Texas | 5 | 15 | 4 | 15 | 0 | 0 | 117 | 23.4 |
| 5 | Old Dominion | 5 | 16 | 6 | 15 | 0 | 0 | 129 | 25.8 |
| 8 | Louisiana Tech | 5 | 18 | 5 | 17 | 1 | 0 | 142 | 28.4 |
| 9 | UTSA | 7 | 19 | 7 | 18 | 0 | 0 | 153 | 21.9 |
| 9 | Southern Mississippi | 6 | 18 | 8 | 18 | 0 | 0 | 150 | 25.0 |
| 11 | Middle Tennessee | 7 | 19 | 6 | 19 | 0 | 0 | 151 | 21.6 |
| 12 | Rice | 5 | 22 | 4 | 21 | 0 | 2 | 169 | 33.8 |
| 13 | Florida International | 6 | 35 | 6 | 31 | 0 | 0 | 259 | 43.2 |
| 14 | Charlotte | 7 | 33 | 5 | 32 | 0 | 0 | 245 | 35.0 |