2021 Conference USA Leaders Scoring Defense - Games at Home Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 5 | 11 | 3 | 10 | 1 | 0 | 87 | 17.4 |
| 2 | UTSA | 7 | 15 | 5 | 12 | 1 | 0 | 119 | 17.0 |
| 3 | Florida Atlantic | 6 | 16 | 3 | 14 | 1 | 0 | 121 | 20.2 |
| 4 | UAB | 5 | 19 | 4 | 15 | 1 | 0 | 143 | 28.6 |
| 5 | Marshall | 6 | 17 | 7 | 16 | 0 | 0 | 139 | 23.2 |
| 6 | Southern Mississippi | 6 | 17 | 5 | 17 | 0 | 1 | 136 | 22.7 |
| 6 | UTEP | 6 | 17 | 6 | 17 | 0 | 0 | 137 | 22.8 |
| 6 | Old Dominion | 6 | 19 | 8 | 17 | 0 | 0 | 155 | 25.8 |
| 9 | Western Kentucky | 6 | 19 | 8 | 19 | 0 | 0 | 157 | 26.2 |
| 10 | North Texas | 6 | 23 | 6 | 22 | 0 | 0 | 178 | 29.7 |
| 11 | Charlotte | 6 | 25 | 4 | 24 | 1 | 0 | 188 | 31.3 |
| 11 | Rice | 6 | 26 | 6 | 24 | 0 | 1 | 200 | 33.3 |
| 13 | Florida International | 6 | 27 | 7 | 25 | 0 | 0 | 208 | 34.7 |
| 13 | Louisiana Tech | 6 | 28 | 5 | 25 | 1 | 0 | 210 | 35.0 |