2021 Conference USA Leaders Passing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 4 | 82 | 42 | 51.2 | 495 | 6.0 | 4 | 1 | 115.59 | 20.5 | 123.8 |
| 2 | Florida Atlantic | 4 | 104 | 52 | 50.0 | 549 | 5.3 | 3 | 5 | 94.24 | 26.0 | 137.3 |
| 3 | Old Dominion | 5 | 134 | 85 | 63.4 | 993 | 7.4 | 11 | 0 | 152.76 | 26.8 | 198.6 |
| 4 | Rice | 4 | 111 | 72 | 64.9 | 927 | 8.4 | 6 | 3 | 147.45 | 27.8 | 231.8 |
| 5 | Southern Mississippi | 4 | 120 | 83 | 69.2 | 1009 | 8.4 | 10 | 2 | 163.97 | 30.0 | 252.3 |
| 6 | UAB | 5 | 151 | 90 | 59.6 | 1293 | 8.6 | 11 | 3 | 151.60 | 30.2 | 258.6 |
| 7 | UTSA | 5 | 155 | 93 | 60.0 | 1277 | 8.2 | 9 | 2 | 145.79 | 31.0 | 255.4 |
| 8 | UTEP | 5 | 160 | 84 | 52.5 | 1098 | 6.9 | 5 | 2 | 117.96 | 32.0 | 219.6 |
| 8 | North Texas | 5 | 160 | 100 | 62.5 | 1218 | 7.6 | 13 | 3 | 149.51 | 32.0 | 243.6 |
| 10 | Western Kentucky | 5 | 167 | 100 | 59.9 | 1330 | 8.0 | 7 | 3 | 137.02 | 33.4 | 266.0 |
| 11 | Marshall | 5 | 170 | 94 | 55.3 | 1123 | 6.6 | 6 | 3 | 118.90 | 34.0 | 224.6 |
| 12 | Middle Tennessee | 5 | 176 | 100 | 56.8 | 1016 | 5.8 | 7 | 7 | 110.48 | 35.2 | 203.2 |
| 13 | Florida International | 4 | 148 | 91 | 61.5 | 1164 | 7.9 | 10 | 1 | 148.51 | 37.0 | 291.0 |
| 14 | Louisiana Tech | 4 | 192 | 141 | 73.4 | 1511 | 7.9 | 13 | 3 | 158.76 | 48.0 | 377.8 |