2021 Conference USA Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | DQ Thomas | MTSU | SR | LB | 1 | 1.0 | 13 | 1.00 |
| 1 | Roderick Brown | N Texas | FR | DT | 1 | 1.0 | 7 | 1.00 |
| 1 | Josh Carr, Jr. | USM | JR | DL | 1 | 1.0 | 7 | 1.00 |
| 1 | Marcus Haynes | ODU | JR | DE | 1 | 1.0 | 6 | 1.00 |
| 1 | Amorie Morrison | ODU | FR | DE | 1 | 1.0 | 5 | 1.00 |
| 1 | Hayes Maples | USM | SO | LB | 1 | 1.0 | 4 | 1.00 |
| 7 | DeAngelo Malone | Western Ky | SR | DE | 2 | 1.5 | 7 | 0.75 |
| 8 | Tyler Grubbs | La Tech | FR | LB | 2 | 1.0 | 13 | 0.50 |
| 8 | Kofi Wardlow | Charlotte | SR | DE | 2 | 1.0 | 11 | 0.50 |
| 8 | Tristan Allen | La Tech | JR | DL | 2 | 1.0 | 7 | 0.50 |
| 8 | Markees Watts | Charlotte | SR | DE | 2 | 1.0 | 5 | 0.50 |
| 8 | Antonio Montero | Rice | JR | LB | 2 | 1.0 | 5 | 0.50 |
| 8 | Ben Bell | La Tech | FR | DL | 2 | 1.0 | 2 | 0.50 |
| 14 | Luke Martin | Charlotte | SR | LB | 2 | 0.5 | 4 | 0.25 |
| 14 | Bryan Wallace | Charlotte | JR | DL | 2 | 0.5 | 4 | 0.25 |
| 14 | Josh Pearcy | Rice | FR | OLB | 2 | 0.5 | 4 | 0.25 |
| 14 | Ikenna Enechukwu | Rice | SO | DE | 2 | 0.5 | 4 | 0.25 |
| 14 | Demetrius Cain | Western Ky | SR | LB | 2 | 0.5 | 2 | 0.25 |
Note: To qualify, player must have played in 75% of his team's games.