2021 Conference USA Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bailey Zappe | Western Ky | SR | QB | 2 | -11 | 853 | 116 | 842 | 7.26 | 421.0 |
| 2 | Austin Kendall | La Tech | SR | QB | 2 | 139 | 610 | 99 | 749 | 7.57 | 374.5 |
| 3 | Chris Reynolds | Charlotte | SR | QB | 2 | 72 | 515 | 74 | 587 | 7.93 | 293.5 |
| 4 | Austin Aune | N Texas | SO | QB | 1 | 55 | 305 | 42 | 360 | 8.57 | 360.0 |
| 5 | Frank Harris | UTSA | SR | QB | 1 | 33 | 280 | 40 | 313 | 7.83 | 313.0 |
| 6 | N'Kosi Perry | FAU | SR | QB | 1 | -19 | 261 | 43 | 242 | 5.63 | 242.0 |
| 7 | Bailey Hockman | MTSU | JR | QB | 1 | -14 | 207 | 36 | 193 | 5.36 | 193.0 |
| 8 | Max Bortenschlager | FIU | SR | QB | 1 | -15 | 185 | 29 | 170 | 5.86 | 170.0 |
| 9 | Wiley Green | Rice | SO | QB | 2 | -1 | 180 | 39 | 179 | 4.59 | 89.5 |
| 10 | Ty Keyes | USM | FR | QB | 1 | 41 | 131 | 36 | 172 | 4.78 | 172.0 |
| 11 | Luke McCaffrey | Rice | FR | QB | 2 | 13 | 95 | 18 | 108 | 6.00 | 54.0 |
| 12 | Hayden Wolff | ODU | FR | QB | 1 | 0 | 88 | 17 | 88 | 5.18 | 88.0 |
| 13 | Jake Constantine | Rice | SR | QB | 1 | -2 | 80 | 18 | 78 | 4.33 | 78.0 |
| 14 | Chase Cunningham | MTSU | JR | QB | 1 | -1 | 76 | 9 | 75 | 8.33 | 75.0 |
| 15 | D.J. Mack Jr. | ODU | JR | QB | 1 | 13 | 39 | 29 | 52 | 1.79 | 52.0 |
| 15 | Tyler Johnston III | UAB | SR | QB | 1 | 2 | 39 | 17 | 41 | 2.41 | 41.0 |
| 17 | Dylan Hopkins | UAB | JR | QB | 1 | -5 | 8 | 10 | 3 | 0.30 | 3.0 |
| 18 | Grayson James | FIU | FR | QB | 1 | -1 | 6 | 3 | 5 | 1.67 | 5.0 |