2021 Conference USA Leaders Total Offense - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bailey Zappe | Western Ky | SR | QB | 2 | 0 | 999 | 115 | 999 | 8.69 | 499.5 |
| 2 | Frank Harris | UTSA | SR | QB | 2 | 82 | 473 | 79 | 555 | 7.03 | 277.5 |
| 3 | Nicholas Vattiato | MTSU | FR | QB | 1 | 9 | 270 | 41 | 279 | 6.80 | 279.0 |
| 4 | Gavin Hardison | UTEP | SO | QB | 1 | 8 | 252 | 32 | 260 | 8.13 | 260.0 |
| 5 | Austin Aune | N Texas | SO | QB | 1 | 28 | 228 | 41 | 256 | 6.24 | 256.0 |
| 6 | Dylan Hopkins | UAB | JR | QB | 1 | -5 | 189 | 28 | 184 | 6.57 | 184.0 |
| 7 | Hayden Wolff | ODU | FR | QB | 1 | -7 | 176 | 29 | 169 | 5.83 | 169.0 |
| 8 | Grant Wells | Marshall | FR | QB | 1 | -6 | 99 | 30 | 93 | 3.10 | 93.0 |
| 9 | Calvin Brownholtz | UTEP | SO | QB | 1 | 2 | 51 | 3 | 53 | 17.67 | 53.0 |
| 10 | Brenden Brady | UTSA | SR | RB | 2 | 97 | 24 | 23 | 121 | 5.26 | 60.5 |
| 11 | Joshua Cephus | UTSA | JR | WR | 2 | 0 | 10 | 2 | 10 | 5.00 | 5.0 |
| 12 | Mike DiLiello | MTSU | SO | QB | 1 | 44 | 6 | 10 | 50 | 5.00 | 50.0 |