2021 Conference USA Leaders Sacks - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Jordan Ferguson | MTSU | JR | DE | 4 | 5.5 | 40 | 1.38 | 
| 1 | Jadrian Taylor | UTEP | JR | DE | 4 | 5.5 | 30 | 1.38 | 
| 3 | Grayson Murphy | N Texas | FR | DE | 4 | 3.5 | 26 | 0.88 | 
| 3 | Praise Amaewhule | UTEP | SO | DE | 4 | 3.5 | 25 | 0.88 | 
| 5 | Clarence Hicks | UTSA | SR | OLB | 4 | 3.0 | 23 | 0.75 | 
| 5 | DeAngelo Malone | Western Ky | SR | DE | 5 | 3.0 | 23 | 0.60 | 
| 5 | Alex Wright | UAB | JR | OLB | 4 | 3.0 | 20 | 0.75 | 
| 5 | Fish McWilliams | UAB | JR | DL | 3 | 3.0 | 12 | 1.00 | 
| 9 | Will Ignont | Western Ky | JR | LB | 5 | 2.5 | 19 | 0.50 | 
| 9 | Juwuan Jones | Western Ky | JR | DE | 5 | 2.5 | 14 | 0.50 | 
| 9 | Dadrian Taylor | UTSA | SR | OLB | 4 | 2.5 | 13 | 0.63 | 
| 12 | TJ Johnson | Marshall | SR | DL | 4 | 2.0 | 23 | 0.50 | 
| 12 | Elijah Garcia | Rice | SR | DL | 4 | 2.0 | 22 | 0.50 | 
| 12 | Michael Pitts | Western Ky | SR | DE | 5 | 2.0 | 15 | 0.40 | 
| 12 | Antonio Moultrie | UAB | JR | DL | 4 | 2.0 | 14 | 0.50 | 
| 12 | Markees Watts | Charlotte | SR | DE | 4 | 2.0 | 14 | 0.50 | 
| 12 | Tristan Allen | La Tech | JR | DL | 4 | 2.0 | 13 | 0.50 | 
| 12 | Eli Neal | Marshall | SO | LB | 4 | 2.0 | 13 | 0.50 | 
| 12 | Tyree Turner | UAB | SR | DL | 3 | 2.0 | 12 | 0.67 | 
| 12 | Justin Thomas | UAB | SR | OLB | 4 | 2.0 | 12 | 0.50 | 
| 12 | Jurriente Davis | MTSU | SO | LB | 4 | 2.0 | 11 | 0.50 | 
| 12 | Gabriel Murphy | N Texas | FR | DE | 4 | 2.0 | 10 | 0.50 | 
| 12 | Trumane Bell II | UTSA | JR | DL | 4 | 2.0 | 9 | 0.50 | 
| 12 | Josh Pearcy | Rice | FR | OLB | 4 | 2.0 | 6 | 0.50 | 
| 25 | Dru Prox | UTSA | SR | ILB | 4 | 1.5 | 13 | 0.38 | 
| 25 | Dion Novil | N Texas | SR | DL | 4 | 1.5 | 12 | 0.38 | 
| 25 | DeQuarius Henry | UTSA | SR | OLB | 4 | 1.5 | 12 | 0.38 | 
| 25 | Marcus Haynes | ODU | JR | DE | 4 | 1.5 | 9 | 0.38 | 
| 25 | Richard Kinley | MTSU | FR | DE | 4 | 1.5 | 5 | 0.38 | 
| 25 | Marcus Bragg | Western Ky | JR | DE | 5 | 1.5 | 5 | 0.30 | 
| 25 | Eriq Kitchen | USM | SR | DL | 4 | 1.5 | 4 | 0.38 | 
| 25 | Darius Shipp | Western Ky | JR | DT | 5 | 1.5 | 4 | 0.30 | 
| 25 | Elijah Alston | Marshall | FR | DL | 4 | 1.5 | 1 | 0.38 | 
| 34 | Charles Wiley | UTSA | SR | OLB | 4 | 1.0 | 22 | 0.25 | 
| 34 | Deidrick Stanley II | MTSU | FR | S | 4 | 1.0 | 20 | 0.25 | 
| 34 | Marley Cook | MTSU | FR | DT | 4 | 1.0 | 13 | 0.25 | 
| 34 | Dennis Barnes | UTEP | JR | DB | 4 | 1.0 | 13 | 0.25 | 
| 34 | Tyson Clawson | Charlotte | FR | DE | 3 | 1.0 | 12 | 0.33 | 
| 34 | Jay Stanley | USM | SO | DB | 4 | 1.0 | 12 | 0.25 | 
| 34 | Josh Ortega | UTEP | SR | DE | 4 | 1.0 | 12 | 0.25 | 
| 34 | Tyler Grubbs | La Tech | FR | LB | 4 | 1.0 | 11 | 0.25 | 
| 34 | Naeem Smith | Rice | SR | S | 4 | 1.0 | 11 | 0.25 | 
| 34 | Jordan Young | ODU | SR | LB | 4 | 1.0 | 10 | 0.25 | 
| 34 | Marlon Krakue | FAU | FR | OLB | 3 | 1.0 | 9 | 0.33 | 
| 34 | DQ Thomas | MTSU | SR | LB | 4 | 1.0 | 9 | 0.25 | 
| 34 | Larry Nixon III | N Texas | SO | LB | 4 | 1.0 | 9 | 0.25 | 
| 34 | Amorie Morrison | ODU | FR | DE | 4 | 1.0 | 9 | 0.25 | 
| 34 | Jahmal Sam | UTSA | SO | S | 4 | 1.0 | 9 | 0.25 | 
| 34 | Trevor Harmanson | UTSA | SR | ILB | 4 | 1.0 | 9 | 0.25 | 
| 34 | George Nyakwol | Rice | SR | DB | 1 | 1.0 | 8 | 1.00 |