2021 Conference USA Leaders Passes Defended - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Quincy Riley | MTSU | FR | CB | 9 | 5 | 9 | 14 | 1.56 |
| 2 | Naeem Smith | Rice | SR | S | 10 | 4 | 3 | 7 | 0.70 |
| 3 | Dy'vonne Inyang | UTEP | SR | DB | 11 | 3 | 7 | 10 | 0.91 |
| 3 | Steven Gilmore | Marshall | JR | DB | 12 | 3 | 7 | 10 | 0.83 |
| 3 | Korel Smith | FAU | SR | CB | 12 | 3 | 6 | 9 | 0.75 |
| 3 | Gabe Taylor | Rice | FR | DB | 10 | 3 | 5 | 8 | 0.80 |
| 3 | Teja Young | FAU | SO | S | 12 | 3 | 5 | 8 | 0.67 |
| 3 | Grayson Cash | UAB | JR | S | 11 | 3 | 4 | 7 | 0.64 |
| 3 | Beanie Bishop | Western Ky | SO | DB | 12 | 3 | 4 | 7 | 0.58 |
| 3 | Gregory Grate | MTSU | JR | S | 13 | 3 | 4 | 7 | 0.54 |
| 3 | Omari Alexander | Western Ky | SR | DB | 13 | 3 | 4 | 7 | 0.54 |
| 3 | BeeJay Williamson | La Tech | SO | DB | 10 | 3 | 1 | 4 | 0.40 |
| 13 | Zyon Gilbert | FAU | SR | CB | 12 | 2 | 10 | 12 | 1.00 |
| 13 | Starling Thomas V | UAB | JR | CB | 11 | 2 | 8 | 10 | 0.91 |
| 13 | Joe Joe Headen | ODU | SR | S | 12 | 2 | 7 | 9 | 0.75 |
| 13 | R'Tarriun Johnson | ODU | JR | S | 12 | 2 | 6 | 8 | 0.67 |
| 13 | Romain Mungin | FAU | SO | CB | 10 | 2 | 5 | 7 | 0.70 |
| 13 | Kahlef Hailassie | Western Ky | SO | DB | 13 | 2 | 5 | 7 | 0.54 |
| 13 | Nazeeh Johnson | Marshall | SR | S | 9 | 2 | 4 | 6 | 0.67 |
| 13 | Miguel Edwards | Western Ky | SO | DB | 11 | 2 | 4 | 6 | 0.55 |
| 13 | Antonio Parks | UTSA | SR | S | 13 | 2 | 4 | 6 | 0.46 |
| 13 | George Nyakwol | Rice | SR | DB | 3 | 2 | 3 | 5 | 1.67 |
| 13 | Lakevias Daniel | USM | JR | DB | 11 | 2 | 3 | 5 | 0.45 |
| 13 | Cory McCoy | Marshall | SR | S | 12 | 2 | 3 | 5 | 0.42 |
| 13 | DQ Thomas | MTSU | SR | LB | 12 | 2 | 3 | 5 | 0.42 |
| 13 | Dennis Barnes | UTEP | JR | DB | 13 | 2 | 3 | 5 | 0.38 |
| 13 | Corey Mayfield Jr. | UTSA | SR | CB | 13 | 2 | 3 | 5 | 0.38 |
| 13 | Jahmal Sam | UTSA | SO | S | 10 | 2 | 2 | 4 | 0.40 |
| 13 | Eric Scott, Jr. | USM | JR | DB | 11 | 2 | 2 | 4 | 0.36 |
| 13 | Davion Williams | Western Ky | SO | DB | 12 | 2 | 2 | 4 | 0.33 |
| 13 | Jon Alexander | Charlotte | SR | DB | 9 | 2 | 1 | 3 | 0.33 |
| 13 | Jay Stanley | USM | SO | DB | 11 | 2 | 1 | 3 | 0.27 |
| 13 | Luke Martin | Charlotte | SR | LB | 12 | 2 | 1 | 3 | 0.25 |
| 13 | Jaiden Cole | La Tech | JR | DB | 10 | 2 | 0 | 2 | 0.20 |
| 13 | Kirk Lockhart | Rice | SO | S | 10 | 2 | 0 | 2 | 0.20 |
| 13 | Kevin Wood | N Texas | SO | LB | 12 | 2 | 0 | 2 | 0.17 |
| 13 | Demetrius Cain | Western Ky | SR | LB | 13 | 2 | 0 | 2 | 0.15 |
| 38 | Roger Cray | ODU | SR | CB | 10 | 1 | 12 | 13 | 1.30 |
| 38 | Teldrick Ross | MTSU | SO | S | 12 | 1 | 12 | 13 | 1.08 |
| 38 | Micah Abraham | Marshall | SO | DB | 12 | 1 | 11 | 12 | 1.00 |
| 38 | Reed Blankenship | MTSU | SR | S | 13 | 1 | 9 | 10 | 0.77 |
| 38 | Natrone Brooks | USM | JR | DB | 11 | 1 | 8 | 9 | 0.82 |
| 38 | Torey Richardson | UTEP | SO | CB | 13 | 1 | 8 | 9 | 0.69 |
| 38 | Malik Shorts | USM | SO | DB | 11 | 1 | 7 | 8 | 0.73 |
| 38 | Rishard Dames | FIU | JR | DB | 12 | 1 | 7 | 8 | 0.67 |
| 38 | Decorian Patterson | MTSU | SO | CB | 12 | 1 | 7 | 8 | 0.67 |
| 38 | Keondre Swoopes | UAB | JR | S | 11 | 1 | 6 | 7 | 0.64 |
| 38 | Jordan Helm | FAU | SR | S | 12 | 1 | 6 | 7 | 0.58 |
| 38 | Tariq Woolen | UTSA | SR | CB | 9 | 1 | 5 | 6 | 0.67 |
| 38 | Dominique Bradshaw | Western Ky | JR | DB | 10 | 1 | 5 | 6 | 0.60 |