2020 American Athletic Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/11/2021
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 1 | 151 | 269 | 67 | 420 | 6.27 | 420.0 |
| 1 | Memphis | 1 | 242 | 271 | 67 | 513 | 7.66 | 513.0 |
| 3 | Tulane | 1 | 179 | 343 | 89 | 522 | 5.87 | 522.0 |
| 4 | Houston | 2 | 420 | 568 | 128 | 988 | 7.72 | 494.0 |
| 5 | Cincinnati | 2 | 211 | 570 | 130 | 781 | 6.01 | 390.5 |
| 6 | Navy | 2 | 429 | 447 | 139 | 876 | 6.30 | 438.0 |
| 6 | SMU | 2 | 443 | 451 | 139 | 894 | 6.43 | 447.0 |
| 8 | East Carolina | 2 | 474 | 607 | 140 | 1081 | 7.72 | 540.5 |
| 9 | South Florida | 3 | 697 | 527 | 199 | 1224 | 6.15 | 408.0 |
| 10 | UCF | 3 | 523 | 1052 | 226 | 1575 | 6.97 | 525.0 |