2018 Conference USA Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 01/07/2019
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 3 | 444 | 601 | 212 | 1045 | 4.93 | 348.3 |
| 2 | UTSA | 3 | 243 | 532 | 209 | 775 | 3.71 | 258.3 |
| 3 | Western Kentucky | 2 | 292 | 441 | 145 | 733 | 5.06 | 366.5 |
| 4 | Louisiana Tech | 2 | 227 | 428 | 139 | 655 | 4.71 | 327.5 |
| 5 | Marshall | 2 | 286 | 490 | 134 | 776 | 5.79 | 388.0 |
| 5 | Rice | 2 | 364 | 204 | 134 | 568 | 4.24 | 284.0 |
| 7 | Florida International | 2 | 187 | 327 | 119 | 514 | 4.32 | 257.0 |
| 8 | Old Dominion | 1 | 137 | 495 | 84 | 632 | 7.52 | 632.0 |
| 9 | UAB | 1 | 111 | 306 | 76 | 417 | 5.49 | 417.0 |
| 10 | North Texas | 1 | 95 | 281 | 75 | 376 | 5.01 | 376.0 |
| 11 | Florida Atlantic | 1 | 132 | 192 | 74 | 324 | 4.38 | 324.0 |
| 12 | Southern Mississippi | 1 | 45 | 215 | 65 | 260 | 4.00 | 260.0 |
| 13 | Charlotte | 1 | 92 | 152 | 62 | 244 | 3.94 | 244.0 |
| 14 | UTEP | 1 | 95 | 39 | 51 | 134 | 2.63 | 134.0 |