2018 Conference USA Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/07/2019
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 1 | 26 | 20 | 0.77 | 0 | 26.00 | 20.00 |
| 2 | Southern Mississippi | 1 | 36 | 96 | 2.67 | 1 | 36.00 | 96.00 |
| 2 | Florida International | 2 | 94 | 461 | 4.90 | 1 | 47.00 | 230.50 |
| 4 | North Texas | 1 | 32 | 126 | 3.94 | 2 | 32.00 | 126.00 |
| 4 | UAB | 1 | 34 | 252 | 7.41 | 2 | 34.00 | 252.00 |
| 4 | Old Dominion | 1 | 49 | 318 | 6.49 | 2 | 49.00 | 318.00 |
| 4 | UTEP | 1 | 50 | 345 | 6.90 | 2 | 50.00 | 345.00 |
| 8 | Marshall | 2 | 74 | 267 | 3.61 | 3 | 37.00 | 133.50 |
| 9 | Western Kentucky | 2 | 77 | 438 | 5.69 | 4 | 38.50 | 219.00 |
| 10 | UTSA | 3 | 111 | 521 | 4.69 | 5 | 37.00 | 173.67 |
| 10 | Florida Atlantic | 1 | 39 | 316 | 8.10 | 5 | 39.00 | 316.00 |
| 12 | Rice | 2 | 76 | 351 | 4.62 | 6 | 38.00 | 175.50 |
| 12 | Middle Tennessee | 3 | 113 | 640 | 5.66 | 6 | 37.67 | 213.33 |
| 14 | Louisiana Tech | 2 | 84 | 507 | 6.04 | 7 | 42.00 | 253.50 |