2017 Conference USA Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/08/2018
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTSA | 1 | 137 | 137 | 58 | 274 | 4.72 | 274.0 |
| 2 | Southern Mississippi | 3 | 387 | 529 | 188 | 916 | 4.87 | 305.3 |
| 3 | Middle Tennessee | 3 | 418 | 600 | 221 | 1018 | 4.61 | 339.3 |
| 4 | Western Kentucky | 2 | 367 | 327 | 131 | 694 | 5.30 | 347.0 |
| 5 | UAB | 1 | 257 | 152 | 80 | 409 | 5.11 | 409.0 |
| 6 | North Texas | 1 | 238 | 197 | 86 | 435 | 5.06 | 435.0 |
| 7 | Louisiana Tech | 2 | 470 | 427 | 127 | 897 | 7.06 | 448.5 |
| 8 | Marshall | 1 | 144 | 341 | 69 | 485 | 7.03 | 485.0 |
| 9 | Charlotte | 1 | 304 | 189 | 74 | 493 | 6.66 | 493.0 |
| 10 | Old Dominion | 2 | 523 | 570 | 165 | 1093 | 6.62 | 546.5 |
| 11 | Florida Atlantic | 1 | 357 | 207 | 84 | 564 | 6.71 | 564.0 |
| 12 | Rice | 2 | 356 | 779 | 140 | 1135 | 8.11 | 567.5 |
| 13 | UTEP | 2 | 506 | 671 | 162 | 1177 | 7.27 | 588.5 |