2016 Mid-American Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Buffalo | 1 | 142 | 258 | 84 | 400 | 4.76 | 400.0 |
| 2 | Eastern Michigan | 1 | 170 | 477 | 78 | 647 | 8.29 | 647.0 |
| 3 | Ball State | 1 | 187 | 266 | 72 | 453 | 6.29 | 453.0 |
| 4 | Central Michigan | 2 | 198 | 709 | 139 | 907 | 6.53 | 453.5 |
| 5 | Ohio | 2 | 227 | 409 | 113 | 636 | 5.63 | 318.0 |
| 6 | Akron | 1 | 294 | 292 | 82 | 586 | 7.15 | 586.0 |
| 7 | Western Michigan | 3 | 310 | 686 | 162 | 996 | 6.15 | 332.0 |
| 8 | Bowling Green | 1 | 359 | 417 | 94 | 776 | 8.26 | 776.0 |
| 9 | Miami (Ohio) | 2 | 411 | 328 | 110 | 739 | 6.72 | 369.5 |
| 10 | Kent State | 2 | 430 | 426 | 149 | 856 | 5.74 | 428.0 |