2016 Big 12 Conference Leaders Long All Purpose Plays - Games at Home Only through 01/09/2017
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | James Washington | Okla St | JR | WR | 7 | 11 | 6 | 4 | 2 | 2 | 2 | 1 |
| 2 | Douglas Coleman | Texas Tech | FR | DB | 5 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 2 | LaQuvionte Gonzalez | Kansas | JR | WR | 6 | 5 | 3 | 3 | 3 | 1 | 1 | 1 |
| 2 | Joe Mixon | Oklahoma | SO | RB | 6 | 7 | 5 | 4 | 2 | 2 | 1 | 1 |
| 2 | Kene Nwangwu | Iowa State | FR | RB | 7 | 6 | 3 | 1 | 1 | 1 | 1 | 1 |
| 2 | Chris Platt | Baylor | SO | WR | 6 | 2 | 2 | 1 | 1 | 1 | 1 | 0 |
| 2 | Byron Pringle | Kansas St | SO | WR | 6 | 8 | 2 | 1 | 1 | 1 | 1 | 1 |
| 2 | Jhajuan Seales | Okla St | SR | WR | 7 | 4 | 1 | 1 | 1 | 1 | 1 | 0 |
| 2 | KaVontae Turpin | TCU | SO | WR | 6 | 7 | 4 | 3 | 2 | 1 | 1 | 0 |
| 2 | Dede Westbrook | Oklahoma | SR | WR | 6 | 8 | 5 | 3 | 3 | 2 | 1 | 0 |
| 2 | Ishmael Zamora | Baylor | SO | WR | 4 | 5 | 1 | 1 | 1 | 1 | 1 | 0 |