2022 American Athletic Conference Leaders Total Defense - All Games through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 13 | 1992 | 2369 | 945 | 4361 | 4.61 | 335.5 |
| 2 | Navy | 12 | 1067 | 3002 | 703 | 4069 | 5.79 | 339.1 |
| 3 | Tulane | 14 | 2132 | 2913 | 1009 | 5045 | 5.00 | 360.4 |
| 4 | Memphis | 13 | 1587 | 3137 | 898 | 4724 | 5.26 | 363.4 |
| 5 | UCF | 14 | 2212 | 3112 | 942 | 5324 | 5.65 | 380.3 |
| 6 | Temple | 12 | 2311 | 2383 | 832 | 4694 | 5.64 | 391.2 |
| 7 | East Carolina | 13 | 1462 | 3806 | 862 | 5268 | 6.11 | 405.2 |
| 8 | Tulsa | 12 | 2495 | 2476 | 846 | 4971 | 5.88 | 414.3 |
| 9 | Houston | 13 | 1859 | 3622 | 928 | 5481 | 5.91 | 421.6 |
| 10 | SMU | 13 | 2647 | 2961 | 934 | 5608 | 6.00 | 431.4 |
| 11 | South Florida | 12 | 2817 | 3384 | 835 | 6201 | 7.43 | 516.8 |