2021 Big Ten Conference Leaders Long Scrimmage Plays - Games vs. FBS Teams With Winning Record Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | TreVeyon Henderson | Ohio State | FR | RB | 9 | 32 | 12 | 8 | 6 | 5 | 2 | 1 | 0 | 0 |
| 1 | Broc Thompson | Purdue | JR | WR | 8 | 10 | 4 | 3 | 2 | 2 | 2 | 2 | 0 | 0 |
| 3 | Braelon Allen | Wisconsin | FR | RB | 8 | 16 | 4 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 3 | Andrel Anthony | Michigan | FR | WR | 9 | 8 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Chris Autman-Bell | Minnesota | SR | WR | 4 | 9 | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Daylen Baldwin | Michigan | SR | WR | 9 | 4 | 2 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 3 | David Bell | Purdue | JR | WR | 7 | 31 | 15 | 9 | 6 | 3 | 1 | 0 | 0 | 0 |
| 3 | Ronnie Bell | Michigan | SR | WR | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Stephen Carr | Indiana | SR | RB | 8 | 12 | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Blake Corum | Michigan | SO | RB | 7 | 13 | 5 | 4 | 3 | 3 | 1 | 0 | 0 | 0 |
| 3 | Aron Cruickshank | Rutgers | JR | WR | 4 | 6 | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Jahan Dotson | Penn State | SR | WR | 6 | 28 | 10 | 6 | 4 | 1 | 1 | 1 | 1 | 0 |
| 3 | Payne Durham | Purdue | JR | TE | 7 | 12 | 3 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 3 | Donovan Edwards | Michigan | FR | RB | 8 | 8 | 4 | 3 | 3 | 2 | 1 | 1 | 0 | 0 |
| 3 | Tyler Goodson | Iowa | JR | RB | 7 | 15 | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Isaac Guerendo | Wisconsin | JR | RB | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | A.J. Henning | Michigan | SO | WR | 9 | 6 | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Evan Hull | N'western | SO | RB | 6 | 18 | 6 | 5 | 2 | 1 | 1 | 1 | 0 | 0 |
| 3 | Cornelius Johnson | Michigan | JR | WR | 9 | 14 | 5 | 3 | 1 | 1 | 1 | 1 | 1 | 0 |
| 3 | Charlie Jones | Iowa | SR | WR | 8 | 9 | 5 | 3 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Chez Mellusi | Wisconsin | JR | RB | 7 | 17 | 4 | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Chris Olave | Ohio State | SR | WR | 8 | 28 | 10 | 8 | 3 | 1 | 1 | 0 | 0 | 0 |
| 3 | Samori Toure | Nebraska | SR | WR | 8 | 19 | 8 | 4 | 3 | 2 | 1 | 1 | 0 | 0 |
| 3 | Miyan Williams | Ohio State | FR | RB | 7 | 16 | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Garrett Wilson | Ohio State | JR | WR | 8 | 34 | 12 | 3 | 3 | 3 | 1 | 1 | 0 | 0 |
| 3 | Roman Wilson | Michigan | SO | WR | 9 | 13 | 8 | 5 | 3 | 1 | 1 | 1 | 0 | 0 |