2021 American Athletic Conference Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Memphis | 1 | 0 | 7 | 7 | 7.00 |
| 2 | Cincinnati | 2 | 4 | 7 | 11 | 5.50 |
| 2 | UCF | 2 | 1 | 10 | 11 | 5.50 |
| 4 | East Carolina | 1 | 1 | 3 | 4 | 4.00 |
| 5 | South Florida | 2 | 3 | 4 | 7 | 3.50 |
| 5 | Tulane | 2 | 2 | 5 | 7 | 3.50 |
| 7 | SMU | 1 | 0 | 3 | 3 | 3.00 |
| 8 | Tulsa | 2 | 2 | 3 | 5 | 2.50 |
| 9 | Temple | 2 | 1 | 2 | 3 | 1.50 |
| 9 | Houston | 2 | 0 | 3 | 3 | 1.50 |