2021 American Athletic Conference Leaders Passes Defended - Games Won Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | East Carolina | 7 | 10 | 38 | 48 | 6.86 |
| 2 | UCF | 9 | 9 | 48 | 57 | 6.33 |
| 3 | Memphis | 6 | 4 | 33 | 37 | 6.17 |
| 4 | Tulsa | 7 | 7 | 31 | 38 | 5.43 |
| 5 | Cincinnati | 13 | 18 | 49 | 67 | 5.15 |
| 6 | Houston | 12 | 14 | 39 | 53 | 4.42 |
| 7 | SMU | 8 | 7 | 25 | 32 | 4.00 |
| 7 | Temple | 3 | 2 | 10 | 12 | 4.00 |
| 7 | South Florida | 2 | 2 | 6 | 8 | 4.00 |
| 10 | Tulane | 2 | 3 | 3 | 6 | 3.00 |
| 11 | Navy | 4 | 2 | 9 | 11 | 2.75 |