2021 Big 12 Conference Leaders Opponent First Downs - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Kansas State | 6 | 43 | 48 | 12 | 103 | 17.2 |
| 2 | Oklahoma State | 7 | 28 | 74 | 14 | 116 | 16.6 |
| 3 | TCU | 5 | 53 | 60 | 11 | 124 | 24.8 |
| 4 | West Virginia | 7 | 54 | 68 | 5 | 127 | 18.1 |
| 5 | Iowa State | 7 | 54 | 66 | 9 | 129 | 18.4 |
| 6 | Oklahoma | 6 | 56 | 70 | 9 | 135 | 22.5 |
| 7 | Baylor | 7 | 52 | 68 | 16 | 136 | 19.4 |
| 8 | Texas | 6 | 68 | 67 | 10 | 145 | 24.2 |
| 9 | Texas Tech | 7 | 58 | 92 | 6 | 156 | 22.3 |
| 10 | Kansas | 6 | 80 | 72 | 7 | 159 | 26.5 |