2021 Big 12 Conference Leaders Opponent First Downs - Games in August/September Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 27 | 21 | 3 | 51 | 17.0 |
| 2 | Iowa State | 4 | 22 | 22 | 2 | 46 | 11.5 |
| 3 | Baylor | 4 | 28 | 32 | 10 | 70 | 17.5 |
| 4 | West Virginia | 4 | 25 | 36 | 8 | 69 | 17.3 |
| 5 | Texas | 4 | 37 | 38 | 2 | 77 | 19.3 |
| 6 | Texas Tech | 4 | 30 | 39 | 7 | 76 | 19.0 |
| 7 | Oklahoma State | 4 | 25 | 40 | 7 | 72 | 18.0 |
| 8 | Kansas State | 4 | 23 | 41 | 6 | 70 | 17.5 |
| 9 | Oklahoma | 4 | 22 | 43 | 6 | 71 | 17.8 |
| 9 | Kansas | 4 | 49 | 43 | 5 | 97 | 24.3 |