2021 Big 12 Conference Leaders Opponent First Downs - Games Lost Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 2 | 9 | 20 | 4 | 33 | 16.5 |
| 1 | Baylor | 2 | 18 | 29 | 4 | 51 | 25.5 |
| 3 | West Virginia | 7 | 56 | 69 | 5 | 130 | 18.6 |
| 4 | Kansas State | 5 | 45 | 57 | 6 | 108 | 21.6 |
| 4 | Oklahoma | 2 | 21 | 18 | 6 | 45 | 22.5 |
| 6 | Iowa State | 6 | 48 | 56 | 8 | 112 | 18.7 |
| 6 | Texas Tech | 6 | 62 | 73 | 8 | 143 | 23.8 |
| 8 | Kansas | 10 | 135 | 98 | 10 | 243 | 24.3 |
| 9 | Texas | 7 | 77 | 80 | 11 | 168 | 24.0 |
| 10 | TCU | 7 | 90 | 71 | 15 | 176 | 25.1 |