2021 Big 12 Conference Leaders Opponent First Downs - Games at Home Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 7 | 41 | 51 | 11 | 103 | 14.7 |
| 1 | Texas Tech | 6 | 41 | 67 | 13 | 121 | 20.2 |
| 3 | Iowa State | 6 | 42 | 41 | 4 | 87 | 14.5 |
| 4 | West Virginia | 6 | 43 | 45 | 10 | 98 | 16.3 |
| 5 | Oklahoma | 7 | 45 | 82 | 12 | 139 | 19.9 |
| 6 | Baylor | 7 | 47 | 72 | 14 | 133 | 19.0 |
| 7 | Texas | 6 | 49 | 60 | 7 | 116 | 19.3 |
| 8 | Kansas State | 7 | 50 | 76 | 4 | 130 | 18.6 |
| 9 | TCU | 7 | 71 | 57 | 10 | 138 | 19.7 |
| 9 | Kansas | 6 | 71 | 50 | 7 | 128 | 21.3 |