2021 Big 12 Conference Leaders Total Offense - Games in December/January Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Spencer Sanders | Okla St | JR | QB | 2 | 154 | 628 | 127 | 782 | 6.16 | 391.0 |
| 2 | Skylar Thompson | Kansas St | SR | QB | 1 | 10 | 259 | 33 | 269 | 8.15 | 269.0 |
| 3 | Donovan Smith | Texas Tech | FR | QB | 1 | 30 | 252 | 33 | 282 | 8.55 | 282.0 |
| 4 | Caleb Williams | Oklahoma | FR | QB | 1 | 34 | 242 | 34 | 276 | 8.12 | 276.0 |
| 5 | Brock Purdy | Iowa State | SR | QB | 1 | 14 | 204 | 44 | 218 | 4.95 | 218.0 |
| 6 | Blake Shapen | Baylor | FR | QB | 1 | -9 | 180 | 37 | 171 | 4.62 | 171.0 |
| 7 | Jarret Doege | WVU | SR | QB | 1 | -22 | 140 | 39 | 118 | 3.03 | 118.0 |
| 8 | Gerry Bohanon | Baylor | JR | QB | 1 | 20 | 40 | 23 | 60 | 2.61 | 60.0 |
| 9 | Brennan Presley | Okla St | SO | WR | 2 | 9 | 6 | 3 | 15 | 5.00 | 7.5 |