2021 Big 12 Conference Leaders Total Offense - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jarret Doege | WVU | SR | QB | 4 | -19 | 1182 | 153 | 1163 | 7.60 | 290.8 |
| 2 | Caleb Williams | Oklahoma | FR | QB | 5 | 220 | 1105 | 125 | 1325 | 10.60 | 265.0 |
| 3 | Skylar Thompson | Kansas St | SR | QB | 4 | -8 | 1074 | 135 | 1066 | 7.90 | 266.5 |
| 4 | Casey Thompson | Texas | JR | QB | 4 | 38 | 989 | 148 | 1027 | 6.94 | 256.8 |
| 5 | Henry Colombi | Texas Tech | SR | QB | 5 | 41 | 959 | 154 | 1000 | 6.49 | 200.0 |
| 6 | Max Duggan | TCU | JR | QB | 5 | 140 | 949 | 153 | 1089 | 7.12 | 217.8 |
| 7 | Brock Purdy | Iowa State | SR | QB | 4 | 102 | 945 | 133 | 1047 | 7.87 | 261.8 |
| 8 | Gerry Bohanon | Baylor | JR | QB | 4 | 56 | 930 | 138 | 986 | 7.14 | 246.5 |
| 9 | Spencer Sanders | Okla St | JR | QB | 4 | 178 | 742 | 138 | 920 | 6.67 | 230.0 |
| 10 | Jason Bean | Kansas | JR | QB | 4 | 116 | 456 | 107 | 572 | 5.35 | 143.0 |
| 11 | Spencer Rattler | Oklahoma | SO | QB | 3 | 15 | 421 | 58 | 436 | 7.52 | 145.3 |
| 12 | Donovan Smith | Texas Tech | FR | QB | 5 | 88 | 262 | 47 | 350 | 7.45 | 70.0 |
| 13 | Chandler Morris | TCU | FR | QB | 1 | 38 | 111 | 22 | 149 | 6.77 | 149.0 |
| 14 | Miles Kendrick | Kansas | SR | QB | 3 | 66 | 89 | 29 | 155 | 5.34 | 51.7 |
| 15 | Shane Illingworth | Okla St | SO | QB | 1 | 6 | 70 | 12 | 76 | 6.33 | 76.0 |
| 16 | Garrett Greene | WVU | FR | QB | 4 | 159 | 48 | 28 | 207 | 7.39 | 51.8 |
| 17 | Hunter Dekkers | Iowa State | FR | QB | 1 | 47 | 29 | 7 | 76 | 10.86 | 76.0 |
| 18 | Blake Shapen | Baylor | FR | QB | 1 | 0 | 18 | 2 | 18 | 9.00 | 18.0 |
| 19 | Ethan Bullock | Okla St | SR | QB | 1 | 9 | 16 | 5 | 25 | 5.00 | 25.0 |
| 20 | Tyquan Thornton | Baylor | SR | WR | 4 | 0 | 6 | 1 | 6 | 6.00 | 1.5 |