2021 Conference USA Leaders Sacks - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Marshall | 12 | 37.0 | 228 | 3.08 |
| 2 | Western Kentucky | 13 | 35.0 | 218 | 2.69 |
| 3 | North Texas | 12 | 34.0 | 237 | 2.83 |
| 4 | UTSA | 13 | 33.0 | 254 | 2.54 |
| 5 | UAB | 12 | 32.0 | 210 | 2.67 |
| 6 | Middle Tennessee | 12 | 29.0 | 211 | 2.42 |
| 7 | Rice | 11 | 25.0 | 184 | 2.27 |
| 8 | UTEP | 12 | 23.0 | 158 | 1.92 |
| 9 | Old Dominion | 12 | 22.0 | 146 | 1.83 |
| 10 | Southern Mississippi | 11 | 21.0 | 142 | 1.91 |
| 11 | Louisiana Tech | 11 | 17.0 | 124 | 1.55 |
| 12 | Florida Atlantic | 11 | 16.0 | 125 | 1.46 |
| 13 | Charlotte | 11 | 15.0 | 112 | 1.36 |
| 14 | Florida International | 11 | 13.0 | 66 | 1.18 |