2021 Conference USA Leaders Sacks - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | North Texas | 7 | 21.0 | 147 | 3.00 |
| 2 | Marshall | 6 | 14.0 | 112 | 2.33 |
| 2 | UTSA | 6 | 14.0 | 105 | 2.33 |
| 4 | Rice | 6 | 12.0 | 92 | 2.00 |
| 5 | UAB | 6 | 11.0 | 77 | 1.83 |
| 5 | Old Dominion | 7 | 11.0 | 77 | 1.57 |
| 5 | Western Kentucky | 7 | 11.0 | 59 | 1.57 |
| 8 | Middle Tennessee | 5 | 10.0 | 59 | 2.00 |
| 9 | Louisiana Tech | 6 | 9.0 | 75 | 1.50 |
| 10 | Florida Atlantic | 6 | 7.0 | 68 | 1.17 |
| 11 | Southern Mississippi | 5 | 6.0 | 26 | 1.20 |
| 12 | Florida International | 5 | 5.0 | 32 | 1.00 |
| 12 | UTEP | 4 | 5.0 | 30 | 1.25 |
| 14 | Charlotte | 4 | 3.0 | 19 | 0.75 |