2021 Conference USA Leaders Total Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 8 | 1515 | 1416 | 497 | 2931 | 5.90 | 366.4 |
| 2 | UAB | 8 | 713 | 1532 | 545 | 2245 | 4.12 | 280.6 |
| 3 | Marshall | 8 | 1419 | 1537 | 584 | 2956 | 5.06 | 369.5 |
| 4 | UTEP | 8 | 1171 | 1632 | 542 | 2803 | 5.17 | 350.4 |
| 5 | Louisiana Tech | 8 | 1480 | 1703 | 548 | 3183 | 5.81 | 397.9 |
| 6 | North Texas | 8 | 983 | 1772 | 520 | 2755 | 5.30 | 344.4 |
| 7 | Florida International | 8 | 2112 | 1990 | 577 | 4102 | 7.11 | 512.8 |
| 8 | Middle Tennessee | 8 | 927 | 2059 | 586 | 2986 | 5.10 | 373.3 |
| 9 | Old Dominion | 8 | 944 | 2268 | 580 | 3212 | 5.54 | 401.5 |
| 10 | UTSA | 9 | 1098 | 2335 | 597 | 3433 | 5.75 | 381.4 |
| 11 | Rice | 8 | 1034 | 2360 | 517 | 3394 | 6.56 | 424.3 |
| 12 | Florida Atlantic | 8 | 872 | 2421 | 563 | 3293 | 5.85 | 411.6 |
| 13 | Western Kentucky | 9 | 1231 | 2423 | 690 | 3654 | 5.30 | 406.0 |
| 14 | Charlotte | 8 | 1311 | 2635 | 516 | 3946 | 7.65 | 493.3 |