2022 FBS Independents Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Notre Dame | 9 | 28.0 | 186 | 3.11 |
| 2 | Liberty | 3 | 13.0 | 106 | 4.33 |
| 3 | Connecticut | 4 | 12.0 | 91 | 3.00 |
| 4 | BYU | 4 | 7.0 | 41 | 1.75 |
| 5 | Massachusetts | 1 | 3.0 | 16 | 3.00 |
| 6 | New Mexico State | 3 | 2.0 | 18 | 0.67 |