2022 Mid-American Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Eastern Michigan | 1 | 170 | 182 | 55 | 352 | 6.40 | 352.0 |
| 2 | Buffalo | 1 | 149 | 297 | 61 | 446 | 7.31 | 446.0 |
| 3 | Ball State | 1 | 218 | 351 | 86 | 569 | 6.62 | 569.0 |
| 4 | Miami (Ohio) | 2 | 157 | 560 | 133 | 717 | 5.39 | 358.5 |
| 5 | Toledo | 1 | 281 | 482 | 78 | 763 | 9.78 | 763.0 |
| 6 | Northern Illinois | 2 | 276 | 558 | 128 | 834 | 6.52 | 417.0 |
| 7 | Western Michigan | 2 | 435 | 412 | 120 | 847 | 7.06 | 423.5 |
| 8 | Central Michigan | 2 | 291 | 643 | 144 | 934 | 6.49 | 467.0 |
| 9 | Ohio | 2 | 397 | 638 | 150 | 1035 | 6.90 | 517.5 |
| 10 | Bowling Green | 2 | 314 | 777 | 157 | 1091 | 6.95 | 545.5 |
| 11 | Akron | 2 | 498 | 674 | 151 | 1172 | 7.76 | 586.0 |
| 12 | Kent State | 3 | 523 | 961 | 219 | 1484 | 6.78 | 494.7 |