2022 American Athletic Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Cincinnati | 3 | 8.0 | 76 | 2.67 |
| 2 | SMU | 2 | 7.0 | 49 | 3.50 |
| 2 | Houston | 2 | 6.0 | 49 | 3.00 |
| 4 | UCF | 3 | 7.0 | 32 | 2.33 |
| 5 | Temple | 2 | 3.0 | 30 | 1.50 |
| 6 | South Florida | 2 | 2.0 | 9 | 1.00 |
| 7 | Memphis | 1 | 1.0 | 8 | 1.00 |
| 8 | East Carolina | 1 | 1.0 | 1 | 1.00 |