2022 American Athletic Conference Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Temple | 9 | 90 | 89 | 9 | 188 | 20.9 |
| 1 | South Florida | 9 | 102 | 129 | 9 | 240 | 26.7 |
| 3 | Navy | 11 | 61 | 103 | 10 | 174 | 15.8 |
| 4 | Tulane | 11 | 108 | 107 | 12 | 227 | 20.6 |
| 5 | Memphis | 11 | 80 | 116 | 13 | 209 | 19.0 |
| 5 | Tulsa | 10 | 95 | 95 | 13 | 203 | 20.3 |
| 7 | East Carolina | 11 | 77 | 145 | 14 | 236 | 21.5 |
| 8 | SMU | 10 | 111 | 102 | 17 | 230 | 23.0 |
| 9 | Houston | 11 | 84 | 138 | 21 | 243 | 22.1 |
| 10 | UCF | 10 | 77 | 110 | 22 | 209 | 20.9 |
| 11 | Cincinnati | 9 | 77 | 75 | 25 | 177 | 19.7 |