2022 American Athletic Conference Leaders Total Defense - Games at Home Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 5 | 329 | 1417 | 311 | 1746 | 5.61 | 349.2 |
| 2 | Tulsa | 6 | 1306 | 1187 | 410 | 2493 | 6.08 | 415.5 |
| 2 | Houston | 6 | 770 | 1758 | 410 | 2528 | 6.17 | 421.3 |
| 4 | South Florida | 6 | 1445 | 1787 | 448 | 3232 | 7.21 | 538.7 |
| 5 | Cincinnati | 6 | 1005 | 1056 | 452 | 2061 | 4.56 | 343.5 |
| 6 | Memphis | 7 | 681 | 1680 | 466 | 2361 | 5.07 | 337.3 |
| 6 | East Carolina | 7 | 736 | 2076 | 466 | 2812 | 6.03 | 401.7 |
| 8 | SMU | 6 | 1180 | 1597 | 468 | 2777 | 5.93 | 462.8 |
| 9 | Temple | 7 | 1279 | 1138 | 471 | 2417 | 5.13 | 345.3 |
| 10 | UCF | 7 | 844 | 1466 | 477 | 2310 | 4.84 | 330.0 |
| 11 | Tulane | 8 | 1175 | 1586 | 592 | 2761 | 4.66 | 345.1 |