2022 Atlantic Coast Conference Leaders Interceptions - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Louisville | 9 | 12 | 252 | 2 | 1.33 |
| 2 | Pittsburgh | 11 | 11 | 193 | 3 | 1.00 |
| 3 | North Carolina State | 10 | 15 | 143 | 1 | 1.50 |
| 4 | Clemson | 11 | 9 | 140 | 2 | 0.82 |
| 5 | Miami (Florida) | 9 | 9 | 104 | 1 | 1.00 |
| 6 | Duke | 10 | 9 | 93 | 1 | 0.90 |
| 7 | North Carolina | 10 | 7 | 80 | 0 | 0.70 |
| 8 | Wake Forest | 10 | 3 | 67 | 2 | 0.30 |
| 9 | Syracuse | 10 | 8 | 52 | 1 | 0.80 |
| 10 | Virginia | 8 | 5 | 40 | 0 | 0.63 |
| 11 | Boston College | 9 | 5 | 38 | 0 | 0.56 |
| 11 | Virginia Tech | 8 | 4 | 38 | 1 | 0.50 |
| 13 | Georgia Tech | 10 | 7 | 26 | 1 | 0.70 |
| 14 | Florida State | 11 | 8 | 10 | 0 | 0.73 |