2022 Atlantic Coast Conference Leaders Scoring Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina | 10 | 36 | 7 | 34 | 1 | 0 | 273 | 27.3 |
| 2 | Clemson | 11 | 28 | 10 | 27 | 0 | 0 | 225 | 20.5 |
| 2 | Syracuse | 10 | 31 | 10 | 25 | 1 | 1 | 245 | 24.5 |
| 2 | Duke | 10 | 32 | 10 | 30 | 1 | 0 | 254 | 25.4 |
| 2 | Miami (Florida) | 9 | 32 | 10 | 32 | 0 | 1 | 256 | 28.4 |
| 6 | Louisville | 9 | 26 | 11 | 26 | 0 | 0 | 215 | 23.9 |
| 6 | Georgia Tech | 10 | 38 | 11 | 36 | 0 | 0 | 297 | 29.7 |
| 8 | Boston College | 9 | 37 | 12 | 30 | 1 | 0 | 290 | 32.2 |
| 9 | Pittsburgh | 11 | 35 | 13 | 30 | 0 | 0 | 279 | 25.4 |
| 10 | North Carolina State | 10 | 25 | 14 | 24 | 0 | 0 | 216 | 21.6 |
| 10 | Florida State | 11 | 29 | 14 | 26 | 1 | 0 | 244 | 22.2 |
| 10 | Wake Forest | 10 | 39 | 14 | 30 | 3 | 0 | 312 | 31.2 |
| 13 | Virginia Tech | 8 | 26 | 15 | 22 | 0 | 0 | 223 | 27.9 |
| 14 | Virginia | 8 | 22 | 18 | 21 | 1 | 0 | 209 | 26.1 |