2022 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Duke | 1 | 8 | 8 | 0 | 16 | 16.0 |
| 2 | Virginia | 1 | 13 | 8 | 0 | 21 | 21.0 |
| 3 | Virginia Tech | 1 | 13 | 8 | 3 | 24 | 24.0 |
| 4 | North Carolina State | 2 | 15 | 14 | 6 | 35 | 17.5 |
| 5 | Pittsburgh | 2 | 11 | 27 | 1 | 39 | 19.5 |
| 6 | Florida State | 2 | 19 | 21 | 3 | 43 | 21.5 |
| 7 | Wake Forest | 2 | 16 | 28 | 2 | 46 | 23.0 |
| 8 | Boston College | 3 | 29 | 30 | 3 | 62 | 20.7 |
| 9 | Louisville | 3 | 35 | 24 | 7 | 66 | 22.0 |
| 10 | Miami (Florida) | 3 | 37 | 32 | 7 | 76 | 25.3 |
| 11 | Clemson | 4 | 38 | 40 | 8 | 86 | 21.5 |
| 12 | North Carolina | 4 | 36 | 43 | 9 | 88 | 22.0 |
| 13 | Syracuse | 4 | 56 | 30 | 6 | 92 | 23.0 |
| 14 | Georgia Tech | 4 | 40 | 45 | 10 | 95 | 23.8 |