2022 Big 12 Conference Leaders Total Defense - Games in August/September Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 302 | 817 | 210 | 1119 | 5.33 | 373.0 |
| 2 | Oklahoma State | 3 | 334 | 796 | 221 | 1130 | 5.11 | 376.7 |
| 3 | West Virginia | 4 | 393 | 818 | 235 | 1211 | 5.15 | 302.8 |
| 4 | Iowa State | 4 | 303 | 761 | 242 | 1064 | 4.40 | 266.0 |
| 5 | Texas Tech | 4 | 399 | 910 | 253 | 1309 | 5.17 | 327.3 |
| 6 | Baylor | 4 | 318 | 903 | 266 | 1221 | 4.59 | 305.3 |
| 7 | Kansas State | 4 | 605 | 773 | 274 | 1378 | 5.03 | 344.5 |
| 8 | Kansas | 4 | 552 | 1058 | 287 | 1610 | 5.61 | 402.5 |
| 9 | Texas | 4 | 540 | 980 | 310 | 1520 | 4.90 | 380.0 |
| 10 | Oklahoma | 4 | 630 | 817 | 314 | 1447 | 4.61 | 361.8 |